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09-12-2013, 12:33 AM | #1 |
YT 2000 Club Donating Member | Not YT related but may be of interest Juvenile Laryngeal Paralysis & Polyneuropathy September 2013 The BRTCA Officers, Board of Directors and members of the Health Committee are pleased to announce that the first major Health Initiative undertaken by the BRTCA will be a research project conducted by Dr. Dennis O’Brien, DVM PhD and Gary Johnson, DVM PhD, at the University of Missouri to research finding a genetic marker for Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) in Black Russian Terriers. While JLPP is by far not the most common problem affecting the breed, we feel that it is the first area to concentrate on because of the devastating effects of JLPP, with a 100% mortality rate in affected puppies. There is no treatment to offer and all will die at between 4-6 months of age. The disease is difficult to diagnose so the true incidence is unknown, as the deaths are generally attributed to respiratory failure, such as pneumonia, which is secondary to the disease. We are just now in the infancy stage of seeing this disease in the United States; however, we know that carriers are present and we feel that it is imperative to find the genetic marker before an explosion of cases develop now that these descendants are of breeding age. Description: The effects of the disease are first seen in the larynx and throat. Affected pups appear to develop normally, but shortly after weaning age they develop difficulty breathing caused by paralysis of the muscle in the larynx (voice box). The muscles fail to pull the vocal folds out of the way when the dog inhales causing a wheezing sound as air flow into the lungs is restricted. The paralysis rapidly progress to the limbs and if the pups have not succumbed to pneumonia first, they ultimately are totally paralyzed and humanely euthanized. JLPP appears to be an autosomal recessive hereditary disease. That is, each parent must be a carrier of the gene. Recessive genes, whether they deal with conformation traits or genetic defects, can stay hidden for generations. Incidence: There is conclusive lab diagnosis of JLPP occurring in three litters in the United States. JLPP is also suspected in two other United States litters and one litter in Canada. Dr. Obrien has information on two affected litters in Europe. Of big concern is that the pedigrees of the documented litters are showing some common lineage which includes some very famous and popular modern lines. Remembering that recessive genes can stay hidden for generations, there are many litters with these ancestors here and around the world that are just coming to breeding age. Without a genetic test, the only way to know if a dog is a carrier is after the disease shows up in a litter. Being a simple recessive inheritance, the statistical odds for an average litter where both parents are carriers are: 25% affected (1-3 pups will die), 50% carrier, and 25% clear. However, more could be affected and die and more could be carriers. More carriers in the breeding pool will increase the probability of producing affected litters in just a few years. Dr. O’Brien believes that this recessive gene has probably been in the breed from its early days, but is just starting to concentrate enough to show up more and be recognized as a genetic disease. Until a marker and DNA test are developed, there is no way, short of diagnosing an affected puppy, of identifying parents as carriers; and surviving puppies of carriers may themselves be unknown carriers that may eventually become part of a breeding pool. The awareness of JLPP in Black Russians has been as a direct result of a few dedicated individuals who recognized a potential genetic problem and took the initiative to make a difference. This is an opportunity for the BRT Community worldwide to step up and work together for the future of the breed. Funding Funding is a major issue. This study will cost $12,000. The study will yield benefits beyond this JLLP project because all of the genetic data will be mapped and can be used in other studies. BRTCA has already contributed $5,000 to the University of Missouri towards the study. Additional funding will need to be raised through direct donations and other fundraising events. It is our hope that the BRT Community will donate to this much needed research project. Donations may be made by check or through the “donation PayPal” link on the website http://www.brtca.org/juvenile-laryngeal-parylasis--polyneuropathy.html. This study needs to happen as quickly as possible, so that these carriers can be identified. It is too important to the future of the breed to delay it any longer. Items that can be sold through the Website to raise funds dedicated to this important research project as well as items donated and ear-marked for the Auction and Raffle at the upcoming National will also be accepted. Our ability to fund this project has been the direct result of the successful nationals we have held and ask you to support our continued efforts to raise funds for health research. Please do whatever you can to help and circulate to any other BRT owners who you may know. Checks can be mailed payable to: Black Russian Terrier Club of America, Inc. 607 Idyllwild Rd. San Jacinto, CA 92583 Additional information on the study and JLPP will be in the next issue of the Footnotes and BRTCA website. BRTCA Board of Directors and Health Committee
__________________ Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018 |
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09-15-2013, 07:03 PM | #2 |
Donating YT 3000 Club Member Join Date: Dec 2011 Location: USA
Posts: 7,652
| Interesting Gail. Amazing how expensive research is. Also, I wonder of the true prevalence of this? and what has been misdiagnosed.
__________________ The Above advice/comments/reviews are my personal opinions based on my own experience/education/investigation and research and you can take them any way you want to......Or NOT!!! |
09-16-2013, 03:40 AM | #3 |
Donating YT 3000 Club Member | Interesting. Thanks for sharing.
__________________ Teri . . . Galen Jameson Frazier Seraphina Luna Rosencrantz, Saber Tooth Tiger, Pussy Willow Pandora Guildenstern |
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