A Warning And A Tearful Request - YorkieTalk.com Forums

Booboo'smommy · 03-23-2007, 06:05 AM

Hi there, I have found this on a site and thought you would all want to have a read as this is serious stuff. This was posted on another site by Zazen 111

Please read and give your oppinion: Here goes:

I am writing this with a heavy heart -our darling Zozzi died at 4 PM this afternoon. Maltie or yorkie owners beware of this insideous disease. I never heard of it and I'm a librarian who does a ton of medical research. Its called Thrombocytocis orf thrombocytopenia.
Our little guy was the picture of happy and healthy dog. Energetic, a huge barker and as owner of about 1000 stuffed animals - a major game player and hide and seeker extrordinaire.
He started showing these wierd little marks on his abdomen about a year ago but we thought they were just typical skin marks - pink, grey, etc. Then suddenly about a week ago my husband noticed they were back (they came and went) with a vengence but we still weren't that alarmed as he was his typical adorable playful self!
Then came the bloody urine, trip to emergency vet, a slight delay waiting to hear from his own vet (grrrrr....) and the wild trip down to U of I in Champaign.
THey didn't really act as swiftly as we would have liked considering how small he was and how much blood he was still losing (via urine) but he still had his typical happy go lucky personality so I guess they didn't think he was as bad off as he was.
Bottom line (I can't bear to write in too much detail right now) even after all the prednisone and a live transfusion from a great dog down there - our little angel went into cardiac arrest - was revived (!!) but then had it again.
Watch out for bruising/wierd marks!! We had no idea this rotten disease even existed. Its internal bleeding (loss of platelets) of the worst sort.
We are utterly distraught and going crazy as it all happened so fast - less than 24 hrs and he was gone.
Now - the request part - does anyone know of a great breeder who has the sweetest and healthiest paper trained puppies in the world, or the US - better the midwest?
Our old breeder is out of business but she was great. SHe raised her puppies in a playpen in her bedroom and paper trained them with Honey Nut Cheerios - and wouldn't part with them until they were about 12 weeks old - and under very careful scrutiny, then.
We have to replace him or go mad - its as simple as that but the new little guy has to be a real sweetie pie - like Zozzi - a bright little beacon of light in our world. Are we asking too much? I hope someone can help. Hubby is still working on his grief but I'm ready now for a new litttle angel to love and, beleive me, we are the best in terms of companions.
Only homemade organic food, fun trips, and tons and tons of love.
Thanks for reading and cherish your own little ones tonight - I would give ANYTHING to hear Zozzi's loud bark again - the one I use to chide him for.
We are definitely open to a puppy-to-be who isn't born yet!!

YORKIEMOM2B2006 · 03-23-2007, 06:19 AM

that is so sad

...I hope she finds another to ease her grief a little

yorkieusa · 03-23-2007, 06:19 AM

I found this and thought it would explain some of the causes of this:

Q: Several dogs seen recently in our clinic have increased numbers of platelets. What does this mean?

A: Many veterinarians in their interpretation of the routine canine CBC often pay little to no attention to the number of platelets, especially if the total platelet count is increased above the normal expected range. This is not good! Therefore, let's proceed with a brief review of canine thrombocytosis.

Platelets are an integral part of the blood's clotting mechanism, enabling the dog's body to control bleeding at the site of injury. When a wound occurs, several changes occur to minimize blood loss. First, the blood vessel slows the flow of blood past the wound site. Next, platelets collect at the wound site to form a plug, which is replaced by a cellular clot until the wound heals.

Platelets are produced in the bone marrow and are removed from the blood by the spleen. Therefore, the bone marrow and spleen work together to regulate platelet numbers in the blood. Platelet numbers can increase because of increased bone marrow production or decreased spleen removal.

Thrombocytosis is defined as increased number of circulating platelets.

Fundamental causes The fundamental causes responsible for thrombocytosis in dogs are:

It may be a temporary response to epinephrine release.
It may be a reaction to a disorder or disease in another part of the body.
It may be a sign of an underlying disease in the bone marrow.

Temporary thrombocytosis may occur in response to exercise, pregnancy and delivery, or other factors causing increased epinephrine levels in the blood. The spleen releases stored platelets in response to temporary increases in blood epinephrine.

Thrombocytosis as a reaction to another disorder in the dog's body results from increased production of platelets in the bone marrow and increased release of stored platelets from the spleen. Clinical problems that may cause a secondary or reactive thrombocytosis are infections, inflammatory disorders, acute or chronic blood loss, tissue damage from trauma or surgery, drugs (steroids, vincristine), hyperadrenocorticism, splenectomy, cancer and rebound from chemotherapy.

Infections (acute and chronic) may cause either reactive thrombocytosis or a thrombocytopenia. Infections may be accompanied by a reactive thrombocytosis, which is thought to be due to cytokines that are produced as part of the body's normal defense against infection.

The reactive thrombocytosis usually resolves as the infection resolves, although it may take longer time to settle into the normal expected range. Inflammatory disorders may also cause reactive thrombocytosis by similar mechanisms to infections.

The response of the bone marrow to acute or chronic blood loss is to produce not only more red blood cells but also more platelets - this occurs in response to cytokines.

The total platelet count will also increase when a relatively large amount of body tissue is damaged either intentionally following surgery or with accidental damage. This is part of the natural defense mechanism to ensure adequate clot formation and prevent fatal bleeding.

Platelet count Treatment with some drugs (steroids, vincristine) causes a transient increase in total platelet count. Underactive or absence of spleen is a major site for destroying platelets, and if the spleen is removed, the total platelet count usually increases. The increase may remain for a long time but usually it will settle back into the normal expected range. In some conditions, the spleen is present but either it does not function properly or it is shrunken and the total platelet count is sometimes increased in these conditions.

Some cancers can cause an increased total platelet count either by causing damage to tissues, causing blood loss or by erroneously producing a cytokine that stimulates the bone marrow to produce platelets. Some chemotherapy drugs exert their effects directly on dividing cells in the body - including the bone marrow where platelets are produced. When the body is recovering from the effects of such chemotherapy, a transient overproduction of some cells can occur, too.

Also, remember that a reactive thrombocytosis is a common observation in canine hyperadrenocorticism.

Potential problems The potential problems arising in a reactive thrombocytosis include excessive clot (or thrombus) formation due to the increased number of active platelets and, much less commonly, bleeding as platelet function may also be defective in reactive thrombocytosis. Although both thrombosis and hemorrhage are potential problems, their occurrence in reactive thrombocytosis is very rare. Generally, they will only occur in dogs with a combination of a total platelet count more than 1,000 million per ml plus other risk factors such as dehydration. The major problems that usually arise in this situation actually relate to the underlying cause of the reactive thrombocytosis.

If reactive thrombocytosis is a response to another disorder, the dog will note signs of that disorder. The primary treatment for a reactive thrombocytosis should be directed against the underlying condition causing the reactive thrombocytosis. In rare circumstances, some treatment to protect against inappropriate clot formation might be advised. Such treatment includes ensuring adequate hydration and optimal mobility. Less often drugs such as aspirin and anticoagulants such as heparin injections may be used.

Essential thrombocytosis, polycythemia vera, chronic myeloid leukemia and myelofibrosis are uncommon conditions that form a group of diseases known as the myeloproliferative disorders. An increased total platelet count can occur in all of these myeloproliferative disorders but in each an increase in a particular cell type usually predominates. These cell types are the platelets in essential thrombocytosis, red blood cells in polycythemia vera, myeloid cell in chronic myeloid leukemia and fibroblasts in myelofibrosis.

The blood disorder that is mostly characterized by an increased total platelet count is primary thrombocytosis - also called essential thrombocythemia. Essential thrombocythemia is one of the myeloproliferative disorders in which the major feature is a thrombocytosis; when the bone marrow is examined there is an increase in the megakaryocytes.

Some dogs with essential thrombocythemia can experience bleeding or clotting problems due to their disease but others have no signs at all. If signs occur, signs may include enlarged spleen, distended abdomen or blood in the stool.
http://dvm.adv100.com/dvm/article/ar...l.jsp?id=19204

michiko · 03-23-2007, 06:26 AM

I am sorry about your loss!

Patti · 03-23-2007, 11:10 AM

I am so sorry to hear your sad news. I hope you find another baby to give your love to soon. I would try Stardust Yorkies in Illinois. I got 13 month old Pixie from her and love her to pieces.

Dina_Nichole · 03-23-2007, 11:17 AM

That is so heartbreaking

I never heard of that disease before and thank you for letting us all know.

ARCHIE · 03-23-2007, 11:21 AM

What a heartbreak that story was to read.
Poor little baby yorkie.
I hope that couple finds a new baby to love soon
and heals the pain in their hearts.

RMKC · 03-25-2007, 09:00 AM

I am so sorry for your loss, you must be soo heartbroken...my thoughts and prayers are with you !

RoxyJosMom · 03-25-2007, 09:10 AM

I am so sorry. Prayers for Zazen111 and her husband. I hope they are able to another little baby soon to help them heal.

judyeve · 03-25-2007, 09:11 AM

I'm so sad for your loss. I hope you find a new furbaby as soon as possible.

Judy

florecita · 03-25-2007, 09:21 AM

That is very sad

yorkieusa...that was very detailed information.....thank you!

judyeve · 04-01-2007, 09:00 AM

i just saw this. I'm so sorry. My prayers are with you.

Judy

Kodak · 04-01-2007, 09:30 AM

This is so sad, I hope she gets a puppy soon to fill the void.

kalina82 · 04-01-2007, 09:36 AM

i'm so sorry for your loss. That's such a horrible way to lose a baby. Hopefully someone here on YT can help you get a new baby. There are tons of wonderful breeders here. good luck and god bless.

Booboo'smommy · 04-02-2007, 12:42 AM

Thank you for all your thoughts. I hope and pray she'll have a new one soon...

03-23-2007, 06:05 AM	#1
Booboo'smommy LUV my 3 Furrs & Alex Donating Member Join Date: Mar 2007 Location: Worcester-UK Posts: 4,621 Blog Entries: 1	A Warning And A Tearful Request Hi there, I have found this on a site and thought you would all want to have a read as this is serious stuff. This was posted on another site by Zazen 111 Please read and give your oppinion: Here goes: I am writing this with a heavy heart -our darling Zozzi died at 4 PM this afternoon. Maltie or yorkie owners beware of this insideous disease. I never heard of it and I'm a librarian who does a ton of medical research. Its called Thrombocytocis orf thrombocytopenia. Our little guy was the picture of happy and healthy dog. Energetic, a huge barker and as owner of about 1000 stuffed animals - a major game player and hide and seeker extrordinaire. He started showing these wierd little marks on his abdomen about a year ago but we thought they were just typical skin marks - pink, grey, etc. Then suddenly about a week ago my husband noticed they were back (they came and went) with a vengence but we still weren't that alarmed as he was his typical adorable playful self! Then came the bloody urine, trip to emergency vet, a slight delay waiting to hear from his own vet (grrrrr....) and the wild trip down to U of I in Champaign. THey didn't really act as swiftly as we would have liked considering how small he was and how much blood he was still losing (via urine) but he still had his typical happy go lucky personality so I guess they didn't think he was as bad off as he was. Bottom line (I can't bear to write in too much detail right now) even after all the prednisone and a live transfusion from a great dog down there - our little angel went into cardiac arrest - was revived (!!) but then had it again. Watch out for bruising/wierd marks!! We had no idea this rotten disease even existed. Its internal bleeding (loss of platelets) of the worst sort. We are utterly distraught and going crazy as it all happened so fast - less than 24 hrs and he was gone. Now - the request part - does anyone know of a great breeder who has the sweetest and healthiest paper trained puppies in the world, or the US - better the midwest? Our old breeder is out of business but she was great. SHe raised her puppies in a playpen in her bedroom and paper trained them with Honey Nut Cheerios - and wouldn't part with them until they were about 12 weeks old - and under very careful scrutiny, then. We have to replace him or go mad - its as simple as that but the new little guy has to be a real sweetie pie - like Zozzi - a bright little beacon of light in our world. Are we asking too much? I hope someone can help. Hubby is still working on his grief but I'm ready now for a new litttle angel to love and, beleive me, we are the best in terms of companions. Only homemade organic food, fun trips, and tons and tons of love. Thanks for reading and cherish your own little ones tonight - I would give ANYTHING to hear Zozzi's loud bark again - the one I use to chide him for. We are definitely open to a puppy-to-be who isn't born yet!! __________________ Mommy 's AlexBoo-BooPheoebeand Snowy WE YT

03-23-2007, 06:19 AM	#2
YORKIEMOM2B2006 Owned by 3 furbabies Donating Member Join Date: Jun 2006 Location: Reading, Pennsylvania Posts: 2,546	that is so sad ...I hope she finds another to ease her grief a little __________________ Elaine, mom to 2 Yorkies Peanut & Dixie

03-23-2007, 06:19 AM	#3
yorkieusa Crazy about Kacee! Donating Member Join Date: May 2005 Location: Kansas Posts: 21,173	I found this and thought it would explain some of the causes of this: Q: Several dogs seen recently in our clinic have increased numbers of platelets. What does this mean? A: Many veterinarians in their interpretation of the routine canine CBC often pay little to no attention to the number of platelets, especially if the total platelet count is increased above the normal expected range. This is not good! Therefore, let's proceed with a brief review of canine thrombocytosis. Platelets are an integral part of the blood's clotting mechanism, enabling the dog's body to control bleeding at the site of injury. When a wound occurs, several changes occur to minimize blood loss. First, the blood vessel slows the flow of blood past the wound site. Next, platelets collect at the wound site to form a plug, which is replaced by a cellular clot until the wound heals. Platelets are produced in the bone marrow and are removed from the blood by the spleen. Therefore, the bone marrow and spleen work together to regulate platelet numbers in the blood. Platelet numbers can increase because of increased bone marrow production or decreased spleen removal. Thrombocytosis is defined as increased number of circulating platelets. Fundamental causes The fundamental causes responsible for thrombocytosis in dogs are: It may be a temporary response to epinephrine release. It may be a reaction to a disorder or disease in another part of the body. It may be a sign of an underlying disease in the bone marrow. Temporary thrombocytosis may occur in response to exercise, pregnancy and delivery, or other factors causing increased epinephrine levels in the blood. The spleen releases stored platelets in response to temporary increases in blood epinephrine. Thrombocytosis as a reaction to another disorder in the dog's body results from increased production of platelets in the bone marrow and increased release of stored platelets from the spleen. Clinical problems that may cause a secondary or reactive thrombocytosis are infections, inflammatory disorders, acute or chronic blood loss, tissue damage from trauma or surgery, drugs (steroids, vincristine), hyperadrenocorticism, splenectomy, cancer and rebound from chemotherapy. Infections (acute and chronic) may cause either reactive thrombocytosis or a thrombocytopenia. Infections may be accompanied by a reactive thrombocytosis, which is thought to be due to cytokines that are produced as part of the body's normal defense against infection. The reactive thrombocytosis usually resolves as the infection resolves, although it may take longer time to settle into the normal expected range. Inflammatory disorders may also cause reactive thrombocytosis by similar mechanisms to infections. The response of the bone marrow to acute or chronic blood loss is to produce not only more red blood cells but also more platelets - this occurs in response to cytokines. The total platelet count will also increase when a relatively large amount of body tissue is damaged either intentionally following surgery or with accidental damage. This is part of the natural defense mechanism to ensure adequate clot formation and prevent fatal bleeding. Platelet count Treatment with some drugs (steroids, vincristine) causes a transient increase in total platelet count. Underactive or absence of spleen is a major site for destroying platelets, and if the spleen is removed, the total platelet count usually increases. The increase may remain for a long time but usually it will settle back into the normal expected range. In some conditions, the spleen is present but either it does not function properly or it is shrunken and the total platelet count is sometimes increased in these conditions. Some cancers can cause an increased total platelet count either by causing damage to tissues, causing blood loss or by erroneously producing a cytokine that stimulates the bone marrow to produce platelets. Some chemotherapy drugs exert their effects directly on dividing cells in the body - including the bone marrow where platelets are produced. When the body is recovering from the effects of such chemotherapy, a transient overproduction of some cells can occur, too. Also, remember that a reactive thrombocytosis is a common observation in canine hyperadrenocorticism. Potential problems The potential problems arising in a reactive thrombocytosis include excessive clot (or thrombus) formation due to the increased number of active platelets and, much less commonly, bleeding as platelet function may also be defective in reactive thrombocytosis. Although both thrombosis and hemorrhage are potential problems, their occurrence in reactive thrombocytosis is very rare. Generally, they will only occur in dogs with a combination of a total platelet count more than 1,000 million per ml plus other risk factors such as dehydration. The major problems that usually arise in this situation actually relate to the underlying cause of the reactive thrombocytosis. If reactive thrombocytosis is a response to another disorder, the dog will note signs of that disorder. The primary treatment for a reactive thrombocytosis should be directed against the underlying condition causing the reactive thrombocytosis. In rare circumstances, some treatment to protect against inappropriate clot formation might be advised. Such treatment includes ensuring adequate hydration and optimal mobility. Less often drugs such as aspirin and anticoagulants such as heparin injections may be used. Essential thrombocytosis, polycythemia vera, chronic myeloid leukemia and myelofibrosis are uncommon conditions that form a group of diseases known as the myeloproliferative disorders. An increased total platelet count can occur in all of these myeloproliferative disorders but in each an increase in a particular cell type usually predominates. These cell types are the platelets in essential thrombocytosis, red blood cells in polycythemia vera, myeloid cell in chronic myeloid leukemia and fibroblasts in myelofibrosis. The blood disorder that is mostly characterized by an increased total platelet count is primary thrombocytosis - also called essential thrombocythemia. Essential thrombocythemia is one of the myeloproliferative disorders in which the major feature is a thrombocytosis; when the bone marrow is examined there is an increase in the megakaryocytes. Some dogs with essential thrombocythemia can experience bleeding or clotting problems due to their disease but others have no signs at all. If signs occur, signs may include enlarged spleen, distended abdomen or blood in the stool. http://dvm.adv100.com/dvm/article/ar...l.jsp?id=19204 __________________ Karen Kacee Muffin 1991-2005 Rest in Peace My Little Angel

03-23-2007, 06:26 AM	#4
michiko The Yorkie Sitter Donating Member Join Date: Sep 2005 Location: Boston Posts: 2,350	I am sorry about your loss! __________________ Michiko (Ethicist) and Haruka(Fragrance of Spring Flowers) [/URL][/COLOR]

03-23-2007, 11:10 AM	#5
Patti Donating YT 30K Club Member Join Date: Oct 2005 Location: Illinois Posts: 35,509 Blog Entries: 6	I am so sorry to hear your sad news. I hope you find another baby to give your love to soon. I would try Stardust Yorkies in Illinois. I got 13 month old Pixie from her and love her to pieces. __________________ Cali Pixie Roxie : RIP Nikki; RIP Maya;RIP my sweet Dixie girl 1/17/08 http://callipuppyscastle.bravehost.com/index.html

03-23-2007, 11:17 AM	#6
Dina_Nichole I Love My Munchkins! Donating Member Join Date: Jul 2006 Location: My Babies ♥'s! Posts: 8,765	That is so heartbreaking I never heard of that disease before and thank you for letting us all know. __________________ I My Lil Furballs!! Pia Mojo ~ Trixie Murphy ~ Paisley Max

03-23-2007, 11:21 AM	#7
ARCHIE No Longer A Member Join Date: Aug 2005 Location: NEW YORK Posts: 16,218	What a heartbreak that story was to read. Poor little baby yorkie. I hope that couple finds a new baby to love soon and heals the pain in their hearts.

03-25-2007, 09:00 AM	#8
RMKC Rosi & Poli's Mom Donating Member Join Date: Mar 2005 Location: Washington State Posts: 5,428	I am so sorry for your loss, you must be soo heartbroken...my thoughts and prayers are with you ! __________________ ROSI & POLI Love my Babies

03-25-2007, 09:10 AM	#9
RoxyJosMom Love The Verminator! Donating Member Join Date: Jul 2006 Location: ny Posts: 4,282	I am so sorry. Prayers for Zazen111 and her husband. I hope they are able to another little baby soon to help them heal. __________________ Roxy loves Alphy Remi loves Millie [COLOR="Purple"]Mom to RoxyJo & Remington , Fozzy Bear & Chloe

03-25-2007, 09:11 AM	#10
judyeve Donating YT 1000 Club Member Join Date: Jul 2006 Location: Brooklyn, NY Posts: 1,729	I'm so sad for your loss. I hope you find a new furbaby as soon as possible. Judy

03-25-2007, 09:21 AM	#11
florecita Senior Yorkie Talker Join Date: Mar 2007 Location: new hampshire Posts: 89	That is very sad yorkieusa...that was very detailed information.....thank you!

04-01-2007, 09:00 AM	#12
judyeve Donating YT 1000 Club Member Join Date: Jul 2006 Location: Brooklyn, NY Posts: 1,729	i just saw this. I'm so sorry. My prayers are with you. Judy

04-01-2007, 09:30 AM	#13
Kodak And Lil Sister Kamari Donating Member Join Date: Nov 2006 Location: Illinois Posts: 2,438	This is so sad, I hope she gets a puppy soon to fill the void. __________________ I'm In Love With 2 Yorkies! http://www.myspace.com/studkodak http://www.dogster.com/dogs/548996

04-01-2007, 09:36 AM	#14
kalina82 Phantom Queen Morrigan Donating Member Join Date: May 2006 Location: with my yorkie baby Posts: 10,141 Blog Entries: 1	i'm so sorry for your loss. That's such a horrible way to lose a baby. Hopefully someone here on YT can help you get a new baby. There are tons of wonderful breeders here. good luck and god bless. __________________ Kellie and Morgan

04-02-2007, 12:42 AM	#15
Booboo'smommy LUV my 3 Furrs & Alex Donating Member Join Date: Mar 2007 Location: Worcester-UK Posts: 4,621 Blog Entries: 1	Thank you for all your thoughts. I hope and pray she'll have a new one soon... __________________ Mommy 's AlexBoo-BooPheoebeand Snowy WE YT