Article in inheritance of liver shunt in Maltese dogs. I found an article from late 2013 about the inheritance of liver shunt and elevated bile acids in Maltese dogs. The work is very preliminary, so it looks like a genetic test is still a ways away. The article is behind a paywall, but here is a link: The inheritance of extra-hepatic portosystemic shunts and elevated bile acid concentrations in Maltese dogs - O'Leary - 2013 - Journal of Small Animal Practice - Wiley Online Library Quoting directly from the article, the main conclusions are: This study represents a preliminary analysis into the inheritance of EHPSS [Extra-hepatic Portosystemic Shunt] in Maltese. While it provides evidence for the genetic transmission of the condition, future work would ideally recruit additional cases and archive DNA to permit whole genome sequencing or genome-wide association studies using canine single nucleotide polymorphism microarrays to identify loci associated with EHPSS and/or PVH [portal vein hypoplasia] in this breed. Indeed, such studies have commenced in Utrecht and Cornell concentrating on dachshunds, Cairn and Yorkshire terriers (van Steenbeek et al. 2012; J. Rothuizen, personal communication). The impact of identified genes on the stunting of the terminal portal veins and regeneration following shunt attenuation would be informative (Furneaux 2011). Definitive identification of PVH with a readily available and minimally invasive test (as opposed to multiple liver biopsies using laparoscopy) would be very helpful as a screening tool, and protein C determinations (Toulza et al. 2006) may achieve this end if used in concert with RATT or advanced imaging. In summary, PSS is inherited in Maltese possibly with a common, partially penetrant, single locus model. Further work, including molecular studies, may help provide further information on inheritance, genetic causes and aetiopathogenesis of EHPSS. This is germane, as prevention is clearly a superior option to surgical correction. |
Thank you for sharing this with us and for all the knowledge you bring to YT. |
Thank you Phil for taking the time to print this....it just blows my mind how all this is unfolding and advancing! |
Quote:
|
Or at the least have established the pathways most likely first to be looked at ! |
Thank you Phil your input is so valuable to we breeders. |
Quote:
|
All times are GMT -8. The time now is 03:42 PM. |
Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright ©2003 - 2018 YorkieTalk.com
Privacy Policy - Terms of Use