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11-03-2014, 12:03 PM | #1 |
YT 3000 Club Member Join Date: Apr 2013 Location: Urbana, IL USA
Posts: 3,648
| Article in inheritance of liver shunt in Maltese dogs. I found an article from late 2013 about the inheritance of liver shunt and elevated bile acids in Maltese dogs. The work is very preliminary, so it looks like a genetic test is still a ways away. The article is behind a paywall, but here is a link: The inheritance of extra-hepatic portosystemic shunts and elevated bile acid concentrations in Maltese dogs - O'Leary - 2013 - Journal of Small Animal Practice - Wiley Online Library Quoting directly from the article, the main conclusions are: This study represents a preliminary analysis into the inheritance of EHPSS [Extra-hepatic Portosystemic Shunt] in Maltese. While it provides evidence for the genetic transmission of the condition, future work would ideally recruit additional cases and archive DNA to permit whole genome sequencing or genome-wide association studies using canine single nucleotide polymorphism microarrays to identify loci associated with EHPSS and/or PVH [portal vein hypoplasia] in this breed. Indeed, such studies have commenced in Utrecht and Cornell concentrating on dachshunds, Cairn and Yorkshire terriers (van Steenbeek et al. 2012; J. Rothuizen, personal communication). The impact of identified genes on the stunting of the terminal portal veins and regeneration following shunt attenuation would be informative (Furneaux 2011). Definitive identification of PVH with a readily available and minimally invasive test (as opposed to multiple liver biopsies using laparoscopy) would be very helpful as a screening tool, and protein C determinations (Toulza et al. 2006) may achieve this end if used in concert with RATT or advanced imaging. In summary, PSS is inherited in Maltese possibly with a common, partially penetrant, single locus model. Further work, including molecular studies, may help provide further information on inheritance, genetic causes and aetiopathogenesis of EHPSS. This is germane, as prevention is clearly a superior option to surgical correction. |
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11-03-2014, 02:47 PM | #2 |
Donating YT 500 Club Member Join Date: Sep 2009 Location: Long Island, New York
Posts: 5,891
| Thank you for sharing this with us and for all the knowledge you bring to YT.
__________________ Lisa and Katie Ashley 6/10, Gracie 2/04, Kiwi 10/03, and Jolie 7/93 . |
11-03-2014, 06:39 PM | #3 |
Rosehill Yorkies Donating YT Member Join Date: Dec 2007 Location: Houston Texas
Posts: 9,462
| Thank you Phil for taking the time to print this....it just blows my mind how all this is unfolding and advancing! |
11-04-2014, 10:07 AM | #4 |
YT 3000 Club Member Join Date: Apr 2013 Location: Urbana, IL USA
Posts: 3,648
| Thanks! My takeaway from the article, in layman terms, is that in Maltese dogs, liver shunt is caused by mutation of a single gene, and the mutation is common. However, the mutation is not completely penetrant, which means that not every dog that carries two copies of the mutation will get the disease. That makes mapping and identifying the gene responsible more difficult, but not impossible, and they are still hopeful and working on it. They don't mention Yorkies in the article, but I'm hopeful that once they isolate the gene in Maltese, they will find that the same gene is affected in Yorkies with liver shunt as well. |
11-04-2014, 11:28 AM | #5 |
YT 2000 Club Donating Member | Or at the least have established the pathways most likely first to be looked at !
__________________ Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018 |
11-04-2014, 11:28 AM | #6 |
YT 2000 Club Donating Member | Thank you Phil your input is so valuable to we breeders.
__________________ Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018 |
11-04-2014, 12:10 PM | #7 |
YT 3000 Club Member Join Date: Apr 2013 Location: Urbana, IL USA
Posts: 3,648
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