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Would you happen to know if there is any effort in the genome sequencing and analysis currently underway to relate the possibility of DNA damage and/or mutations that might have been due to intake of transgenic (GMO) products (such as the Starlink/Starlight corn cross-pollenation issue) or mutagens such as the free unbound glutamates (msg) which are excitatory neurotoxins and are routinely added, according to some researchers and ingredient lists, to many pet and human food products. I realize this question may cross a line where you have confidentiality, so if that is the case, I will not expect you to violate that trust. But, you have likely heard of Pottenger's cats, and you have already mentioned mutated DNA...which I would think would show up in a DNA sequence, so I was wondering if you think it is possible that the researchers may discover that some of the high incidence of 'thought to be hereditary' health issues within familial lines could be related/due to mutagenic pollutants in food, water, air, etc. Just curious...:D |
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L2-Hydroxyglutaric Aciduria (excessive hydroxyglutaric acid in the urine) is different from Hyperuricosuria (excessive uric acid in the urine)--two different chemicals. For those who are scratching their heads over COI, it means "coefficient of inbreeding," a measure of how inbred your breeding population is. Here is a link to a layman's description: A Beginner’s Guide to COI – Dog Breed Health |
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Sadly my young lass died of lymphoma and was cremated before I even knew this was asked for, and I would have contributed if I did know. Why can't these research organizations get some idea on how to put this information out to all breed clubs in America and Canada? Just saying |
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[QUOTE=pstinard;4227561]Hi, the transgenic corn that is out there so far is nontoxic from a health standpoint--yeah, I know it's controversial to say that, but that seems to be the scientific consensus. There could be allergic reactions on an individual basis, but no wholesale health problems. Additives are more problematic, but the FDA assures us they are safe--again, there could be individual allergic reactions. My personal opinion is that additives unrelated to improving nutritional content should be avoided where possible. Pollutants are another matter entirely. Some of them are mutagens and cancer-inducing, soQUOTE] So just exactly what are pollutants? Fertilizers , genetic mutations to the core of what a plant was? Cutting the core out of a wheat germ kennel to mix with another kernel? Fiddling with the DNA of a certain plant to make them resistant to a certain bug and not understanding that that company put to death a certain insect or bee or wasp or fly that fed on this crop before it was a mutant? So for me, my first love and care is for dogs. I home feed my dogs with organic ingredients I search out, andare home feed my family. We are all of us are at a cusp of science and technology that can nuture and help us. But judiciously. We need bioethics experts not only in the human world but in the dog world |
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I, too, make a very concerted effort to research every ingredient as far into its past as possible, back to the manufacturer's website and often beyond...and I reject most products based on my research, unfortunately, because I do not feel certain constituents should be consumed if one wishes to be well or have their pets be well and healthy. I know for an absolute fact that, after being fed fairly decent, nutritionally sound foods, my dogs and cats won't touch many products...which I suppose is good in a way. Stores that offer treats could do it without me there and my Yorkies will shun them without me having to tell them to Leave It. The physical changes that Pottenger observed with generations of cats were specifically related to their diet. It is very interesting reading, and I feed my babies as close to a species specific, nutritionally viable diet as possible. |
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Thank you. I very much value your opinion. It is nice to have the benefit of one who studies and practices in the field of genetics to comment on what possibilities might exist that might be affecting the real world results we have to deal with. For those who breed these darling Yorkies, it is of primary importance to avoid anything that might set back their breeding programs or cause genetic harm to their lines. I am not a breeder, but, on their behalf, and mine as well, I would like to thank you for all you have shared with us. :) |
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:thumbup: It is very exciting...rather like opening a somewhat mysterious gift! :D |
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Having said that; if we could find the genetic markers of HD and ED, I would kiss the ground!. Even more information and studies on how to through nutrition and early rearing practices, and later puppy feeding and practices minimize the severity of this condition. I have found only one European study to date that with a relatively small sample size, has found out some interesting things. ON early nutrition, surfaces, feedings, and appropriate exercise. Another USA paper through statistical analysis postulates that horizontal information is more usefull than the vertical pedigree for this scourge of large breeds. Interesting theory. And then there is the all important spay and neuter question to boney growth and disease in those self same joints! And the pre-ponderance of evidenced base research is now finally now! growing. To be an intelligent breeder, to give advice and support, to give instructions, to put your name and reputation behind your breedings, not to mention the financial implications of disease in your pups, is a huge undertaking. I am not a not a Pet Breeder, nor will I ever be!. I am a show and working dog breeder. Trying my best to balance out the facets of a good working dog, married to what the show ring demands, in terms of coat and acceptable show temperament, head carriage, ear set, head configuration, tail length, etc. Those things I set out are for the most part un-important for the working dog. Except bite. We for the most part have a marriage of interests in structure. In internal organ health. Not so much in other more minor in our eyes things that happen in the conformation rings. To me always is the health of my dogs, the dogs I breed, and what they might pass on to any of my puppies. I want always to produce very fine examples of the breed, that are healthy! And as a sidenote, they do always look like BRT's! |
I kinda feel dumb reading this thread :D |
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For gemy, I found the following link that might be of interest: Bioiberica develops the first DNA test to determine genetic predisposition to hip dysplasia in dogs - News and events | Bioiberica There's also another scholarly article that might be behind a pay firewall, but for what it's worth, here is the link: Canine hip dysplasia is predictable... [Osteoarthritis Cartilage. 2011] - PubMed - NCBI |
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Never feel dumb. In my mind you are here and reading this thread, almost de-facto you are interested in the health and genetics of breeding. As a pet owner, and a future pet owner, it is good to educate yourself, on these various threads. It will always help to inform your next decision. I do use short-forms quite frankly as it is faster to do on typing, and those of us that know, know these short forms. Keep reading, keep learning. I do! |
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