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What heart condition did she die from? |
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From Genetics of Deafness in Dogs Genetic transmission of deafness in dogs with the piebald (sp) and extreme white piebald (sw) pigment genes, such as the Dalmatian, is less clear. These genes affect the amount and distribution of white areas on the body. Deafness in Dalmatians does not appear to be autosomal dominant, since deaf puppies result from hearing parents. It does not appear to be a simple recessive disorder, since we have bred pairs of deaf Dalmatians and obtained bilaterally hearing and unilaterally hearing puppies, when all should have been deaf if the disorder was recessive. These findings might be explained by a multi-gene cause, the presence of two different autosomal recessive deafness genes, or a syndrome with incomplete penetrance. Further studies (in progress) will be required to determine the mechanisms. Several candidate genes known to cause pigment-related deafness in humans or mice have been eliminated as the possible cause of pigment-associated deafness in Dalmatians. Whole-genome screens will hopefully identify the cause in this and other breeds. Here is a link to more information about deafness in white spotted dogs: DDEAF FAQ's And a full length scientific article: http://www.lsu.edu/deafness/VetJDeaf2004.pdf Deafness is related to white pigmentation, because melanin is required in the ears for hearing. |
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Thanks for the reading material I want to understand this. p.s. do you think her heart disease was in relation to the deafness? Stupid question I'm sure...but just curious if you've heard of that combo. |
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There is no such thing as a stupid question. I did a search for any relationship between white coat color, deafness, and heart disease, and found no connection of heart disease to coat color or deafness. The heart disease is probably something that developed separately. Sorry for the loss of Mia 1 :(. |
Thanks Phil. For sure you are a Godsend, when my aged memory, and my sad lack of search skills combine. I was pretty sure there was a deaf/piebald link. Heart disease is also twigging here, although I did read you researched and found no link... to deafness; but how about albinos? This might be a wives tale I heard 30 or more years ago. |
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I am not sure if this applies in this case but there is a connection with deafness and heart disease in humans. This is the article I read a few months ago. I did not believe I kept the link but here it is if anyone is interested: Something You Don't Hear Much About: Hearing Loss Tied To Heart Disease Humans and canines do share a small percentage of genetic material but what are the odds it would include this. The article is from 2005 so maybe there is current information. Just thought I would share it. |
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Thanks for posting that Tricia. Interesting stuff. for sure. |
Brady is a Blue Merle I'm about 10 years late but I made it! I have a blue merle. If you are still out there, here's some pics! |
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Ckc registered |
There are two CKC CKC-Continental Kennel Club or and CKC-Canadian Kennel Club Which CKC is your "Blue Merle" registered with because there "is" a deference. |
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Still love him and do not care! thanks |
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