New News coming on Hypothyroidism Development of Accurate Diagnostic Tests for Canine Hypothyroidism | AKC Canine Health Foundation Very interesting research, and also the funders of the research This is the most common endocrine disorder in dogs. |
Dr. Jan A Mol, PhD, University of Utrecht November 1, 2014 - October 31, 2015 Sponsor(s): Treeing Walker Breeders & Fanciers Association, American Shih Tzu Club, Inc., Great Pyrenees Club of America, Tibetan Terrier Club of America/Tibetan Terrier Health & Welfare Foundation Breed(s): -All Dogs Disease(s): Hypothyroidism Research Program Area: Endocrinology Donate to Support this Grant Abstract Primary hypothyroidism is one of the most common endocrine disorders in dogs. The insufficient secretion of thyroid hormones may result in severe physical and mental changes, such as lethargy, alopecia, obesity, decreased cardiac output, and decreased renal perfusion. The diagnosis of hypothyroidism is sometimes problematic. The circulating thyroxin (T4) concentration is below the reference range in most dogs with primary hypothyroidism, but T4 is not very specific as it can also be low in sick dogs with a normal thyroid function, i.e., dogs with non-thyroidal illness (NTI). However, a combination of a low T4 concentration and a clearly elevated plasma thyroid stimulating hormone (TSH) concentration is a definitive proof of hypothyroidism. Unfortunately, about 30% of dogs with primary hypothyroidism have a TSH concentration within the reference range and therefore cannot be distinguished from dogs with NTI. Consequently, either dogs with NTI are unnecessarily treated with thyroxin supplementation or dogs with primary hypothyroidism may lack proper treatment. Dr. Mol and colleagues propose to investigate 3 methods that may provide a more accurate diagnosis than the currently available tests for practitioners. They will test whether 1) a stimulation test with measurements of plasma growth hormone and TSH concentrations, 2) the plasma TRH or ghrelin concentration, or 3) a reporter assay for plasma thyroid hormone bioactivity, can be used to differentiate between dogs with primary hypothyroidism and dogs with NTI. Publication(s) None at this time. - See more at: Development of Accurate Diagnostic Tests for Canine Hypothyroidism | AKC Canine Health Foundation I found that part really interesting. |
Yes, Gail, this is important! Thank you for posting. How did you get this news? |
I am linked into many health websites and I regularly check for new research developments. THe AKC is just one. |
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