I completely understand what your going through. My one girl is a complete wreck. Her little tougue comes out and she pants immediately. She's does this during the entire trip. Could be 5 min or 3 hrs. I hold her while my fiance drives and I do everything to make her comfortable but nothing works. I don't look foward to the trip home (3 hrs ) for Christmas. She makes me a nervous wreck. If anyone knows anything that is safe for them to take please let me know. Thanks !! Good Luck to everyone else that deals with this