I HAVE HAD A FEW LITTERS AND I THINK PERSONELLY THAT IT IS GENETICS...my puos are stasndard Yorkie pups, 3-7 lbs. at maturity and none have ever needed Nutra-Cal or Drops. Mine play hard, but my bloodline is stong and sturdy like pioneer women. my female had 9 pups in an hour, laid on 2 after 4 dAys, so we had 7 pups and i kept one from last litter. thast is Itseys pic under my name, she wassnt 2lbs till 13 weeks. now she is pushing 4lbs at almost 8 months........never had nutra-cal and i'm proud of itr ad so are my clients. i have it but never had to use it. My pups like all Yorkies run 500mph it seems when they play and play hard, no one has ever had problems, so make sure you check your bloodlines or breeders. i buy only stong dogsthat dont have low blood or liver shunts or knee problems. i dont want a dog that shakes either. that is what i want a cobby short leg bodied square cute yorkie 3-5 lbs. Brittany