My little girl, Ashley, also began to act much more anxious and restless at night, and we also noticed some other subtle changes the last year of her life. We discovered she had Canine Cognitive Dysfunction at the age of sixteen. Anipryl helped her anxiety and confusion. It wasn't a Miracle drug, but it allowed Ashley to still have a good quality of life, even with her dementia. Preventing Ashley from jumping off of the bed was challenging, even though she had a ramp she was used to.
It may not be related at all to this, but here is a checklist that might help. I didn't think it was possible, but we grew to love Ashley even more during this period of her life. I wouldn't have given up a second with her.
http://www.cdsindogs.com/PDF/CDSInDogs/ANIPRYL.pdf
If there is anything I can do to help, please let me know.