Do your sister a favor and click on the search button here on YT and type in breeding tinies. Maybe if you show your sister these articles and also what goes into breeding she will have second thoughts. Breeding is not a one time adventure to get another dog as any time can be dangerous for these little ones. Alot of testing needs to be done to be sure the female can handle having a litter along with many expensive tests that need to be done on the puppies. I would hate to have your sister lose her baby because she didn't know the risks.
It is excellent that you are asking the question and using the search link will give you lots of answers.
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