Like I said I would never leave them unsupervised at ANY time. And if this is a breed targeted discussion... Then that's too bad. I know mike from Alaska has a big lab with his two yorkies... No problems yet huh? I am sure there are others here with big breeds and small ones that live harmoniously
Also like i said he has been raised with 4 small dogs since he was 6wks old. I would never bring a dog into my home if I thought he would kill either.