To the OP- are you sure the pup wasn't given epinephrine (adrenaline) with the sub q fluids? If a reaction is strong enough to require oxygen and fluids, it's generally strong enough to require something other than just benadryl. Benadryl takes too long to be absorbed to do any good during an acute anaphylactic episode. The epinephrine would increase blood pressure and heart rate during the time you were waiting for the Benadryl to kick in.
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