We just flew from Newyork to Miami on Sunday with Isabella, we are still here. She got a little fussy when we first got on the plane and then as soon as we took off, she fell asleep and slept for the 3 hours, we didn't give her any sedatives, I think it was the sound of the engine. I am hoping she will do just as well on the trip back home. Good Luck on your trip, hope she sleeps for you, and I was the one who took the sedative, works wonders
.