A neutered male can still breed a females so even if your have your boys neutered you will need to keep them separated from your girl when she is in heat.    If you have no intentions of breeding her then I recommend you have her spay before her next heat.     Remember that the heat cycle last 3 whole weeks so you will need to keep her away from the boys about 4 weeks to be safe.   Keeping the female out of sight of the boys will be your best option for keeping them calmer but even with that they will probably still act crazy.     |