Have you taken Holly to your vet since you got her at 10 weeks? Holly has probably only had one round of shots and she'll need several more plus rabies to be fully immunized. If she hasn't had all her shots she could be at great risk for dangerous puppy diseases like Parvo which you can carry in on your shoes.
If shots are started before about nine weeks, maternal antibodies from nursing block their effectiveness. They also need the last set around 18-20 weeks when the antibodies are completely out of their system to be fully protected.
Dr. Dodd's vaccination protocol is an excellent one to follow.
W Jean Dodds Vaccine Protocol VACCINATION PROTOCOLS