This in from an insecticide factsheet on the use of fironil as in Frontline.....
Effects on Reproduction
Frontline and fipronil also disrupt reproduction and development. In the study mentioned in the preceding paragraph, a single dose of Frontline approximately doubled the time between periods of estrus in female rats.18 (Estrus describes the time when a female is able to conceive; in many mammals this occurs in cycles.19) Higher doses of Frontline also reduced the number of female rats who were able to become pregnant following
mating.18
Studies conducted as part of fipronil’s registration process also documented
effects on reproduction. Offspring of rats fed fipronil during pregnancy
were smaller than offspring of unexposed rats. In addition, male offspring
from exposed mothers took longer than offspring of unexposed mothers to mature sexually. These effects occurred at all but the lowest
dose level tested. In another study, fipronil reduced litter size, fertility, and
the survival of offspring. These effects occurred at the highest dose level
tested.20
When pesticides are toxic to the nervous system, exposure during pregnancy
might damage the developing nervous system of the unborn child. The first experiment mentioned in the preceding paragraph was designed to
test for this kind of effect. It showed that the offspring of rats exposed to
fipronil had smaller brains than the offspring of unexposed rats. (See Figure
4.) In addition, the fipronil exposure caused a variety of behavioral
changes. All of these effects occurred at the highest dose level tested.21,22
If anyone would like to read more it's here.....
http://www.pesticide.org/fipronil.pdf