Years ago, after having clear skin all through High School, my acne started. First was the antibiotics, which didn't help, along with all the creams. RetinA, I'm sure you've heard of it. When my acne started I was having terrible problems with my menstrual cycle. I ended up having a hysterectomy at age 32. It wasn't until then that my acne cleared up. From age 24 until 32 I took Accutane on and off until my hysterectomy. I had the usual side effects, but it did help my acne. The problem was, by the time I started taking Accutane, I already had scaring. When I had my hysterectomy, my doctor left on ovary, so I didn't have to take hormone replacment. Don't know if this helps or not, but I know what you mean about getting depressed when you have acne. That's been years ago, and I wonder what the long term effects are. Keep your chin up!