I just talked to my vet today and he said that I should go ahead and worm pups and mom now and then test later (@ about 6-8 wks) to see if needed to be wormed again. He uses Nemex. I wasn't sure as they are only 2wks old, but he assured me that it is safe this early. Btw all the boys have just reached 1 lb. so are exteme rolly pollies.