ok good news she has pneumonia now but came out of sedated state yesterday and ate. She dodged a bullet and yorkie prayers again. I just want to let you know the sequence of events and final reasoning for all this so it does not happen to another dog.
Multiple oral dosing of ketoconazole increases dog exposure to ivermectin
What happened is Ketoconazole should never be given with ivermectin. Keto allows the ivermectin to break the blood brain barrier thus allowing the drug to go to the brain causing seizures, coma and death in many cases. Ivermectin is a drug that affects neurologically the mites and heartworm thus killing them which in high doses if it breaks the blood brain barrier wall can do to your pet.
Sophie was on ivermectin off and on for a year at .11 the problem was it was increased and given with ketoconazole which should have never been done and dermatologist admitted her mistake.
Now for the other errors sophie was sedated thursday at 8:00 am at vets office then stopped at 10:00 am but did not come to all day -- my vet said it is like sleeping beauty they wake up after days so told me to tell her to hang in there. Well she was transported to specialty hospital where they sedated her with a drug called Midazalom which is like valium sedating sophie for 24 hrs to stop seizures but sophie stopped seizing 24 hrs prior but do to her having tremors trying to detox they thought it was seizures and sedated her and she could not swallow so they suctioned her trachea causing fluid to go to the lungs now pneumonia -ugh then she had a fever and was transported to the hospital where derm is an hour a way to cut down costs and for her to help care for her with a team of specialists. She was transported with a hot water bottle ( bc ivermectin toxicity causes body temp to drop) and she had a fever so could have caused her to seize again so another error. Luckily she did not seize she was now diagnosed with pneumonia friday and treated with antibiotics and fluids and no sedation drugs and she came out of state yesterday and ate and hopefully will be home today.
what a disaster but she is obviously a fighter despite all the errors she still lived -- Yorkies are tough.
Please when you get drugs from your vet call the manufacturer and ask questions before giving your dog drugs and if your dog has a reaction stop drug immediately and always go with your gut if you feel something is just not right as we know our dogs better than anyone.