I use Advantix. I don't know about all of them but the ticks will go on them but not attach and then crawl off them and die. The same with fleas. The medication stops them from biting and then causes them to die but you may still find one crawling around. I think this is the same for all the topical. I chose not to give oral meds, I'm more uncomfortable with that then the topical. If given a choice I would use nothing but we have tons of ticks so I had to make a choice. He has never reacted to the Advantix but I only use half the amount as he is only 3lbs 12oz. Good luck!
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