I do! I'm super paranoid about germs and bacteria. No shoes are allowed in the house! And the wood floors get constantly wiped down.
Their paws gets cleaned nightly with a damp towel or alcohol and fragrance free baby wipes . I buy them in bulk now at Costco.
They are used to it by now and don't make any fuss. They sometimes step in their soiled pads and get stinky. If we take them outside, they get their paws washed in the sink or a full on bath.