I have shipped puppies that were 12 weeks plus and always have to get a rabies shot. I get the shot several days before sending the puppy so I can monitor the reaction, and I make sure there are at least a few days between the rabies and the third DHPP so the immune system has time to recover. You may also want to give Albon, or Albon/Metro compound for a few days to help prepare them for the stress of the shipping. I also mix Dyne with water and freeze the water bowl ahead of time in the deep feeze. This will help in keeping the nutrition level during transit. Hope this helps!