Haven't experienced it on one of my dogs no....maybe this article will help:
There are few things more frustrating than swollen lymph nodes and a non-specific pathology report on them. It is unfortunate, but lymph nodes enlarge for a lot of reasons. It is always a good idea to carefully repeat the physical exam, looking for new clues as to what is going on. Sometimes, a general lab panel, X-rays or bacterial cultures can be helpful in finding the cause of the lymph node enlargement. We see this pretty frequently in our practice secondary to allergies. I am not sure if the lymph nodes enlarge as a direct result of the allergy or because secondary skin infections are common with allergies -- but they are frequently enlarged in dogs with chronic allergy problems. The most serious concern is lymphoma (cancer of the lymph nodes). Removal of the node is helpful in diagnosing this, obviously.
An intermediate step prior to removal of another node might be to aspirate several of the lymph nodes and send smears of the aspirates to the pathologist. We do this before removing lymph nodes in many cases and often the diagnosis can be made from the aspirate.
Source:
http://www.vetinfo4dogs.com/dlymph.h...0lymph%20nodes