I did try (<---try being the optimal word) when Baby was a baby b/c it came with her "puppy kit." Needless to say, she didn't use them at all, and now she is trained...well, about 70% so far, to go outside. We do not have any pee pads in the house.
But that doesn't mean there isn't pee pee and poo on the floor!
The "best" way in my opinion, would be to have a dog that was 100% trained to use both! That way, when you were home you would take him/her out. But, if you were running late, you knew you wouldn't have to rush home to take out the dog b/c he/she would know to use the pads. That way...no messes. But, I wonder if there are dogs like that.