well when they combine the booster and the rabies.. is when layla has problems.. so they suggest to give the booster one day.. and then a week later give the rabies... it is so much for their tiny bodies to deal with. my vet said that a yorkie gets the same dose as a great dane because they ahve the same amount of somehting or other.. but the yorkies obviously have a much more concentrated amount in their body.. poor layla can't breathe right and gets a fever.. you should suggest the spacing to your vet