Well, it all depends. If it's a really hard plastic bone (like a Nylabone) she still has them from when she was a pup. If it's a doggy loofah/soft and fuzzy, a few months until she pulls all the fuzz off. If it's that soft squeaky plastic, not even a day!!! See example below. Glad (Jaspermom) bought this for Baby, and in a few minutes she ripped Mr. Wishbone's nose off!!!