I don't think that bigger always means healthier; however, the smaller the dog is the quicker it can go down hill if it does get sick. We have a very small male and an small female and both are really healthy.
Single pups are most of the time bigger than pupps born in a litter bc they do get all of the extra both before and after birth. I wouldn't worry about your puppies weight though. Most Yorkies have such a high metobolic rate that as active puppies they will thin down pretty fast once they get to moving. Here is a picture of our chubby out of the litter. He is only 5 days old here, and already weighs a third of his dads weight.
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