I've always heard that male/female is the best pairing because of the natural chemistry - they will get along. The next choice would be two males and (I was told) that two females together is not great - that they call them "bitches" for a reason, lol. THIS ISN'T MY OPINION - this is what breeders have told me. I love the boy/girl combination. Oscar is my goldenboy and Ruthie is my babygirl.