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It all comes down to your opinion. Some prefer Frontline and others prefer Advantix.
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That is what my vet said too when I asked which is better. She recommended them both and said it was a personal perference. We are currently using Advantix just because it has the added benefit of helping with misquitoes, which are bad around here.
We have used Frontline too, year back and didn't have any complaints on it. AND I think they are priced about the same.
I wish they worked better......well, IMO, they just don't seem to work like I would think.....course, I guess, in my rosy world, I think Mojo shouldn't have a tick on him since we use this stuff, but that isn't how it works.....darn!!!