We have a 3 1/2lb Yorkie and an 80lb Boxer and Georgie (Yorkie) tears Coco up LOL! He has renewed Coco and she plays now more than ever (she is almost 7).My brother has 2 labs and a Yorkie and they get along great
I would just watch them initially to make sure the lab doesn't get excited and pounce around, but for the most part I think they are a great combination. Here is a pic of my niece with our 2 furbabies