I have a 1 lb 12 oz yorkie that will be 5 months old tomorrow. Now we havent had ANY problems yet, and hope not ever (knock on wood). She is a real go getter. She gives my 12 lb Bichon a run for her money!! There doesent seem to be anything fragile about her, other than if you were to drop her or something to that effect. I think someone else nailed it ,when they said most of it depends on their genes and family background. This has just been our experience. Good luck in finding your new little bundle of joy!!