I have a tiny runt of the litter yorkie. She's tiny but man is she tough. I haven't had a bad experience with a smaller than standard yorkie. She was breed from standard size parents though, that probably makes a difference because of the genes. Her parents are healthy, standard yorkies and she's tiny but has strong bones, strong health and I have never ever had any hypoglycemia problems or other health related issues. I'm just in love with her and the only issue she has is that she can't get away from my kisses