I'm speaking in generalities, since I have done multiple brands, from multiple vets in multiple states. And then you have things like Triheart. The boxes frequently come in small/medium/large dogs, and the small dogs it's usually "Small Dogs (<15 lbs)". Well, my Yorkie was less than half that. So a dose for a dog twice as large is going to be large for him. I'd like to cut the pill in half, but I was told not to because the drugs are a cocktail. The dog that I have left--not a Yorkie--weighs about 15 lbs, so the side effect is not so much. If you look up Ivermectin, lethargy is clearly a common side effect. I just lived with it.
They like the cocktails up in Canada and New York. The danger of Lyme exceeds the danger of Trifexis. My yorkie got Lyme, and I will never know whether it affected him permanently.
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