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Strychnos nux-vomica, the strychnine tree, also known as nux vomica(strychnine is toxic in large doses)
https://www.medicalnewstoday.com/articles/323447

Nux vomica: Uses and risks
Nux vomica is the common name for a homeopathic medication that comes from the Strychnos nux-vomica tree, which is also called the vomiting nut or the poison nut tree.
Of the research that is available, it is essential to note that the studies may focus on one specific part of the plant, such as the flower, seed, or leaf.
Therefore, the results may not be the same for all parts of the plant.
Possible benefits of nux vomica include:
Antioxidant effects
A Chinese study noted that there are many different compounds in nux vomica that make it a potent antioxidant.
This research may show that nux vomica could have some potential benefits. However, the same study also confirms that the two major active compounds, brucine and strychnine, are poisonous at high doses.
Pain relief
A 2015 study found that the extract from nux vomica leaves has a promising analgesic, or pain-relieving, effect. The researchers said this could be due to the antioxidants in the plant.
However, the homeopathic treatment comes from the seeds, not the leaves.
Other researchers studied the effects of removing much of the strychnine from the seed. Their research found that removing this compound improved the analgesic and anti-inflammatory effects of nux vomica.
The researchers said that this was probably due to the presence of brucine. Brucine reduced swelling and markers of pain in an animal model. More research is needed to determine if it has the same effect in humans.
UNDER “OTHER RESEARCHERS”
https://www.sciencedirect.com/science/article/abs/pii/S0378874111007914
Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: Effect of changes in alkaloid composition
Abstract
Ethnopharmacological relevance
Strychnos nux-vomica L. (Loganiaceae) is grown extensively in southern Asian countries. The dried seed of this plant, nux vomica, has been clinically used in Chinese folk medicine for improving blood circulation, relieving rheumatic pain, reducing swelling and treating cancer.
Aim of the study
This study was carried out to investigate the effect of removing most strychnine from the total alkaloid fraction (TAF) extracted from nux vomica on analgesic and anti-inflammatory activity and pharmacokinetics after transdermal administration.
(Strychnine represents up about 30%–50% in TAF composition extracted from the processed nux vomica. It is obvious that with the removal of most of the strychnine MTAF could display significantly increased therapeutic efficacy in antitumor, analgesic and anti-inflammatory applications.)

Materials and methods
Most strychnine was removed from TAF and the resulted modified total alkaloid fraction (MTAF) was obtained.The contents of strychnine and brucine in TAF and MTAF were determined. Then the analgesic and anti-inflammatory activity of TAF, MTAF, brucine and strychnine dissolved in hydrogel was compared after transdermal administration. Furthermore, in vitro and in vivo transdermal absorption profiles of brucine after administration of TAF, MTAF and brucine dissolved in hydrogel were also compared.
Results
In contrast to TAF, most strychnine was removed from MTAF and the ratio of brucine to strychnine was adjusted from 1:1.8 to 2.7:1. MTAF showed significant analgesic activity in all the chemical-, thermal- and physical- induced nociception models, which indicated the presence of both centrally and peripherally mediated activities. MTAF also showed significant anti-inflammatory activity against xylene-induced ear edema. But TAF and strychnine demonstrated little activity in all those pharmacological tests. Brucine showed to be effective in acetic acid-induced writhing and xylene-induced ear edema test. Brucine in MTAF was absorbed more completely than it alone at the same dosage of brucine after transdermal administration.
Conclusions
The results from the present study appeared to support the viewpoint that most strychnine should be removed from TAF to improve analgesic and anti-inflammatory activity. The relatively higher pharmacological activity of MTAF compared to brucine alone is partly due to the enhanced transdermal absorption of brucine.
The results from the present study appeared to support the viewpoint that most strychnine should be removed from TAF to improve analgesic and anti-inflammatory activity. The relatively higher pharmacological activity of MTAF compared to brucine alone is partly due to the enhanced transdermal absorption of brucine.




The main ingredients in Double P II are:

There are 21 ingredients that go into the making of Double P ll

Ba Ji Tian warms Yang and tonifies Kidney
Bu Gu Zhi tonifies Kidney Yang and strengthens bones
Chi Shao cools Blood and resolves stagnation
Chuan Niu Xi tonifies Kidney Yang and strengthens rear limbs
Chuan Xiong activates Blood and resolves stagnation
Dang Gui nourishes Blood, activates Blood, and relieves pain
Di Long clears internal wind and detoxifies
Du Zhong strengthens back and tonifies Kidney Yang
Fu Zi warms Yang and Channels
Gan Cao harmonizes
Gu Sui Bu strengthens bones and tonifies Kidney Yang
Hong Hua moves Blood and resolves stagnation and stasis
Huang Qi tonifies Qi
Ma Qian Zi activates Channels, relieves pain, and clears Wind-Damp AKA Nux vomica
Mo Yao resolves stagnation and relieves pain
Quan Xie resolves stagnation
Ru Xiang resolves stagnation and relieves pain
Tian San Qi moves Blood, stops hemorrhage
Wu Gong moves Qi and relieves pain
Xu Duan strengthens bones and ligaments, tonifies Kidney Yang
Xue Jie resolves stagnation