Hello! We just took Wall-e on his 3rd round trip flight, although actual travel time was only 7 hrs with a layover. It went well. I got him a mild tranq from the vet. It just calmed him down, didn't make him sleep though. Airline carriers vary in attractiveness. I do like the Argo, I found one for $30 on eBay. Sleepypod is a really nice one too, but only if you want to shell out the money for them. Wall-e travelled in the cabin with us. The first leg of the trip, the flight attendant was very nice and I was able to hold Wall-e in my lap. The 2nd leg the flight attendant had a major attitude problem, and started giving me a hard time about having a dog before I even got to my seat! So he stayed in the carrier. It all depends. A flight attendant friend of mine says the less of a big deal you make about bringing the dog on board the better. For instance when you are boarding, keep the pup in the carrier, zipped up. Don't advertise that you have them with you. But like I said, it depends on the person.
If you have a layover, I recommend using the disabled stall in the restroom (as long as no one needs it!) and put a pee pad on the floor for them to use quickly. I find the pet areas in airports are too far away to use. I brought treats with me and a water bottle for him that I had to wait to fill after we went through security. It went pretty smooth!
Good luck!
__________________ Here comes Wall-e!  and now Daisy too!  |