Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time - Sorenmo - 2003 - Veterinary and Comparative Oncology - Wiley Online Library
Veterinary and Comparative Oncology, March, 2003. 10.1046/j.1476-5829.2003.00007.x
Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time
K. U. Sorenmo, M. Goldschmidt, F. Shofer, C. Goldkamp, J. Ferracone
Abstract
The purpose of this study was to characterize canine prostate cancer using immunohistochemical staining specific for acinar and urothelial/ductal tissue and correlate these results with the dogs' castration status/castration time. Seventy dogs with prostate cancer were included, 71% were castrated and 29% were intact. Compared with an age-matched control population, castrated dogs were at increased risk of prostate cancer, odds ratio 3.9. Immunohistochemical staining was performed on 58 cases. Forty-six of the 58 stained positive for cytokeratin 7 (CK 7) (ductal/urothelial origin) and one of the 58 stained positive for prostate-specific antigen. Dogs with CK 7-positive tumours were younger when castrated than dogs with CK 7-negative tumours, 2 versus 7 years (P = 0.03); dogs castrated at ≤2 years of age were more likely to be CK 7-positive (P = 0.009). These results show that most canine prostatic carcinomas are of ductal/urothelial, androgen-independent origin. This is consistent with the epidemiological findings, showing increased risk in castrated dogs. Canine prostate cancer may, therefore, not be a realistic model for the human disease.
Figures No figures found. http://www.yorkietalk.com/forums/dat...ABAAEAAAIBRAA7 Figure 1 | Immunohistochemistry, validation of staining specificity. (A) Normal control prostate in an intact male dog: strong positive staining with prostate-specific antigen (PSA) in acinar tissue, ×300; (B) normal prostate of neonatal dog (21 days): negative staining with PSA, ×150; (C) normal prostate in a mature castrated dog: strong positive staining with cytokeratin 7 (CK 7) in prostatic ducts, ×300; (D) normal prostate: strong positive staining of prostatic ducts with CK 7, no staining of acinar tissue, ×300; (E) normal prostate of neonatal dog (21 days): strong positive staining of prostatic ducts with CK 7, ×150; (F) normal bladder epithelium: strong positive staining with CK 7, ×300
http://www.yorkietalk.com/forums/dat...ABAAEAAAIBRAA7 Figure 2 | Immunohistochemistry, canine prostatic carcinoma. (A) Strong positive staining with cytokeratin 7 (CK 7) in a male castrated dog, ×300; (B) weak multifocal staining with prostate-specific antigen (PSA) in an intact male dog, ×300; (C) negative staining with CK 7 in an intact male dog, ×300.
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