Sakura has seasonal allergies everytime the seasons changes and has itchy paws.  When it gets really bad I give her some prescription Vetadryl.  Benadryl just made her throw it up.  I also see that if the hair between her paw pads starts getting long she chews too.  Keeping her paws trimmed helps too.
 
If the Benadryl didn't do anything I would say get the fur trimmed between her paw pads.  It always helps Sakura.  
