I haven't tried Nexgard, mostly because I'm reluctant to try things that haven't been used for a while. As 107 Barney said, I would guess that it will work for Lyme deer ticks if it works for American dog ticks. I use Heartgard and Advantix II or Frontline Plus, but I'd love to stop using a topical. There is a current rebate if you use both Heartguard and Nexgard.
http://www.nexgardfordogs.com/Style%...cs/coupon.html