I've been using it a while now. I split one dose and she went downhill over those two weeks. So last week, I have her a medicated bath and reapplied a whole dose and she's back to shining like a mink coat. But it's high time for allergies here so she's back on daily Atopica. Hard to say what works entirely for Daisy as she needs the whole "cocktail" but I do really love the allerderm