I lost my sweet little girl, Promise, yesterday after a very quick struggle with acute kidney disease. She was fine for 11.5 years and then I put her on Trifexis. Six months later, she is gone. The symptoms of kidney disease are so slow in showing up that by the time I realized what was happening, it was way too late. She was in the hospital for 2 nights being hydrated and her bloodwork looked a bit better yesterday morning. But, the vet said there was no way she would EVER be the same, maybe 40% with weekly IV's and vet care. Creatine level was over 5, which means that 75% of her kidneys were damaged. I feel, in my heart of hearts, that the poisin Trifexis is the main contributor to her disease. The guilt I am feeling right now is overwhelming and the flashback to the look on her little face as her life drained from her 1.9 lb body is crippling. I don't think I will ever get over this. Just needed to vent today.