Some of the questions I would ask is "How many times have you bred this female?(it kind of throws warning signs to me if someone breeds their dog everytime it goes into heat) Is this a pair you've bred before? What does their offspring look like? Is there a history on either sides of the lines for health issues? Can I speak to your vet to confirm everything you've told me? Do you have any references/ any buyers that I could speak with? Can I come by to see where the puppies are raised?" There are tons more questions and I'm sure the members here will provide you with some really good one's I've never thought of