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Originally Posted by gemy  Pstinard: research what the solution was for the rampant hyperuricosuria defect in Dalmations.
I should not post, as my memory is a little vague on the details. But the breeders were asleep at the switch as it were, and finally had no viable breeding dogs to breed as this dominant gene was rampant throughout the breeding world of Dalmations.
Now one very brave breeder did something about this. How-ever his motives were to save this lovely breed, and did it very knowingly and with knowledge. He did have to outcross, and then spent a long time, breeding back into purebred Dalmations without this very un-healthy gene.
What this person is doing, is not of the same ilk, in my mind. |
Hi, I'll park some links here so people can read up on this. If any of these are behind firewalls, I'll quote the relevant parts later. Cross breeding might be fine for a breed of dog in which ALL individuals are affected by a genetic disease, but there are still plenty of healthy breed standard Yorkshire Terriers. The people doing cross breeding with Yorkies are doing so in order to breed in "lovely" coat colors.
Mutations in the SLC2A9 Gene Cause Hyperuricosuria and Hyperuricemia in the Dog About The Dalmatian Heritage Project - Dalmatian Puppy Breeding & Adoption - Hayward, California Exclusion of Urate Oxidase as a Candidate Gene for Hyperuricosuria in the Dalmatian Dog Using an Interbreed Backcross A Dalmatian Study—The Genetic Correction of Health Problems By Robert H. Schaible, Ph.D.