At 16 weeks, we did rabies. I think we finished puppy shots around the same time. We do rabies, and DHPP (no lepto). The shots can be separated but honestly dogs are more likely to react to the BOOSTER shot not puppy shots. I would definitely hang out at the vet for a good half hour after the DHPP shot to make sure the pup doesn't react. Rabies, I just leave because it's pretty infrequent that dogs react to rabies. As for lepto, I would definitely stay at the office for this one as well if you do it. I would not do lepto at the same time as DHPP. These are my personal views, and you should discuss your concerns w/ your veterinarian who should be more than delighted to explain things to you.
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