Usually the pups I have open their eyes within a day of each other. The male in my Wilma's litter (born 1-13-06) opened his eyes 4 days after his sister... and he is the biggest of the two (a little chunky).
I agree to use a cotton ball soaked in warm water to wash out their eyes.
I had to do this for the female a few days after her eyes opened as one of her eyes closed back up.