Here's my line of thought: Since the pup has been on hormone suppressing drug a good amount of time, coming off this drug allows his system to start producing hormones again. His body may be reading that as overproduction, causing the rise in ALP (if that iso is responsible... further testing needed). So it's not that the fluconizole is helping the liver directly, but indirectly by suppressing the hormone production. Or his system has gone wacky and is overproducing the hormones. IDK.
Here's a great link:
http://veterinarymedicine.dvm360.com...date=&pageID=2
Also rule out Lepto and any tick borne disease. I'd keep him on Denamarin indefinitely. Thinking about Doxycycline but not sure if okay with liver involvement.