I use k9 Advantix II for Sophie every month along with Heartguard Plus and she acts the same way. Rolling around trying to get it off and low growling showing her displeasure. It only lasts for about two or three minutes and she's fine again. She actually loves the Heartguard (treat
). We have a large deer population here so I use it twelve months to guard against ticks. She hasn't had a flea or tick since we began with these products (knock on wood)