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Rebecca Ann · 05-27-2012, 11:59 AM

We have an 8 year old Yorkie, but this is about our 2.5 year old Beagle. We were given a supply of Trifexis from the vet and gave the first months dose to him on Friday around 1pm. He was playing and happy when we left around 5pm. Upon returning at 9pm I found him sleeping on the bed and acting very tired and lethargic. Upon getting ready for bed around 11pm he was still laying in the same spot and I noticed some tremors in his legs. Yesterday morning we woke to him shaking and breathing very funny. He was craning his neck back and panting. When he tried to get up to go outside he had a difficult time standing and was shaking badly. He hesitated going down our front two steps as if he didn't think he could do it. I ended up carrying him back into the house because he just stood in the lawn shaking with his tail pulled in tight and his neck drawn at a strange angle. We called the vet and took him straight into emergency. The vet believed he was having a reaction to the Trifexis and called their hotline. She came back and said that they told her they had not received neurological complaints as long as the dose was administered properly -- she checked and assured us it was the proper dose and that his weight was actually at the high-end for that dosage. She informed us she would be on call all of this holiday weekend if we had problems but that she thought it would pass within a couple of days and he would feel better.

All day yesterday and through the night he shook with tremors, was lethargic, acted very disoriented, was extremely weak and his eyes looks glazed over. He also seemed oblivious to activity around him, no response if you said his name, etc.

Today is Sunday afternoon. It has been over 48 hours since he took the Trifexis tablet. He is just starting to show some signs of feeling a little better - wagging his tail a tiny bit etc - but he is still weak, just laying on the bed with his head down, when he does try to walk he seems very unsure of himself and walks very slowly. He is still having tremors but they are not as bad as yesterday and last night.

I realize all animals react differently. My suggestion if you are going to give this to your dog is make sure you stay with them to watch for adverse reactions. I could understand throwing up or diarrhea, but the neurological problems our dog is going through is very frightening and has turned an active, playful, healthy dog into a trembling, zoned out pitifully weak pup within a few hours. We will never give this to any of our animals again.

In researching Trifexis yesterday, I have found many people who's dogs have experienced the same side effects ours had and even a few "suspected" Trifexis related deaths. Our dog was only given his first dose but it appears other dogs have appeared fine only to have a bad reaction after later doses.

This was off of another board:
"Be careful! There have been reports of neuro problems showing up but most have about 2-3 months worth of doses and then their system just can't take anymore."

05-27-2012, 11:59 AM	#17
Rebecca Ann YorkieTalk Newbie! Join Date: May 2012 Location: Indiana Posts: 1	Horrible reaction to Trifexis We have an 8 year old Yorkie, but this is about our 2.5 year old Beagle. We were given a supply of Trifexis from the vet and gave the first months dose to him on Friday around 1pm. He was playing and happy when we left around 5pm. Upon returning at 9pm I found him sleeping on the bed and acting very tired and lethargic. Upon getting ready for bed around 11pm he was still laying in the same spot and I noticed some tremors in his legs. Yesterday morning we woke to him shaking and breathing very funny. He was craning his neck back and panting. When he tried to get up to go outside he had a difficult time standing and was shaking badly. He hesitated going down our front two steps as if he didn't think he could do it. I ended up carrying him back into the house because he just stood in the lawn shaking with his tail pulled in tight and his neck drawn at a strange angle. We called the vet and took him straight into emergency. The vet believed he was having a reaction to the Trifexis and called their hotline. She came back and said that they told her they had not received neurological complaints as long as the dose was administered properly -- she checked and assured us it was the proper dose and that his weight was actually at the high-end for that dosage. She informed us she would be on call all of this holiday weekend if we had problems but that she thought it would pass within a couple of days and he would feel better. All day yesterday and through the night he shook with tremors, was lethargic, acted very disoriented, was extremely weak and his eyes looks glazed over. He also seemed oblivious to activity around him, no response if you said his name, etc. Today is Sunday afternoon. It has been over 48 hours since he took the Trifexis tablet. He is just starting to show some signs of feeling a little better - wagging his tail a tiny bit etc - but he is still weak, just laying on the bed with his head down, when he does try to walk he seems very unsure of himself and walks very slowly. He is still having tremors but they are not as bad as yesterday and last night. I realize all animals react differently. My suggestion if you are going to give this to your dog is make sure you stay with them to watch for adverse reactions. I could understand throwing up or diarrhea, but the neurological problems our dog is going through is very frightening and has turned an active, playful, healthy dog into a trembling, zoned out pitifully weak pup within a few hours. We will never give this to any of our animals again. In researching Trifexis yesterday, I have found many people who's dogs have experienced the same side effects ours had and even a few "suspected" Trifexis related deaths. Our dog was only given his first dose but it appears other dogs have appeared fine only to have a bad reaction after later doses. This was off of another board: "Be careful! There have been reports of neuro problems showing up but most have about 2-3 months worth of doses and then their system just can't take anymore."