Charlize Theron played serial killer Aileen Wuornos, and because the makeup made her look so much like Aileen, I don't think many people thought of Charlize when they saw the movie, or for that matter thought of Aileen when they saw Charlize in her own makeup. What I'm trying to say, is if they use makeup to create a look-a-like, it shouldn't hurt anyone's career.
220px-Charlize_Theron_by_Gage_Skidmore.jpg Charlize
monster9.jpg Charlize as Aileen
monster2.jpg Charlize as Aileen
aw2.jpg The real Aileen
I think Shannon Doherty could do a good job at it and it if she does, it would help her career.