I used the Frontline Plus on my cats and the ticks seemed to thrive on it. There is not another approved topical for cats against ticks and they are the ones that bring the ticks into the house. My only defense has been to flea comb them when they come in to get the unattached ticks off them so they don't find their way to Gracie. Then I use the tick puller to get off any embedded ones.
I don't know of anything that kills them before they bite. I have already found two ticks and it is March! I dread thinking of what it will be like this summer.
